The most effective of the group are those with the longest half-life, such as oxfendazole, fenbendazole, albendazole, and their prodrugs, because they are not rapidly metabolized to inactive products. Effective concentrations are maintained for an extended period in the plasma and gut, which increases efficacy against. Treatment is with albendazole, mebendazole, or ivermectin. (See also Approach to Parasitic Infections.) Ascariasis occurs worldwide. It is concentrated in tropical and subtropical areas with poor sanitation. Ascariasis is the most common intestinal helminth infection in the world. Prevalence is highest in children aged 2 to
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